This is an observational study of people who have musculoskeletal pain to determine whether having a positive (ACPA) blood result, means that they are more likely to develop Rheumatoid Arthritis. We are also investigating close relatives of people with RA. The study looks at investigating the risk factors of those who may develop Rheumatoid Arthritis and to see if we can prevent them from developing the disease.
Research has shown that a combination of joint pain (arthralgia) and the presence of specific antibodies in the blood can identify people at high risk of developing Rheumatoid Arthritis. This study investigates the effects of treating these people using a drug called abatecept ( already licensed for treatment of patients with established Rheumatoid Arthritis) to better understand the immune and inflammatory responses at the earliest detectable stages of the disease.
This study will look at genetic, environmental, and other factors to understand what makes people more or less likely to develop rheumatoid arthritis in people who are first degree relatives of those diagnosed with RA. This will be done using questionnaires and blood tests.