Within this research theme, we will:
(b) Deliver intervention studies to achieve disease cure/remission in early/established rheumatoid arthritis respectively through the precise use of immunotherapies by patient phenotyping and understanding of disease and drug mechanism.
(c) Develop intervention studies based on stratified prognosis at different disease stages, with the ultimate aim of disease prevention in autoantibody-mediated diseases or disease remission/ cure for those presenting with established disease
(d) Improve the management of immune mediated inflammatory diseases through accurate phenotyping and knowledge of drug mechanisms and treatment toxicity, particularly those associated with glucocorticoids
Aim: In individuals at risk of developing rheumatoid arthritis, we will expand our local investigations to
nationally validate biomarkers, develop risk models, and using stratified populations, develop proof of concept studies to prevent disease progression.
Aim: In early and established rheumatoid arthritis, we will aim for disease cure and remission respectively through the precise use of immunotherapies; by accurate phenotyping of response, identification of response predictors and understanding of refractory rheumatoid arthritis.
Aim: Develop intervention studies through stratified prognosis at different disease stages, with the aims of disease prevention in autoantibody-mediated diseases or disease remission/cure for those with established disease in two areas: systemic sclerosis and psoriatic arthritis.
Aim: Improve the management of established immune mediated inflammatory diseases through accurate molecular phenotyping applying knowledge of pathogenesis, drug mechanisms and treatment toxicities, particularly infections and those associated with glucocorticoids.