This research theme will build on the scientific advances in imaging and diagnostics, understanding of structural pathology and cell therapies. Our distinctive capabilities in novel regenerative scaffolds and devices, improved methods of simulation and design, enhanced pre-clinical testing and imaging capabilities to understand the OA phenotype will enable us to develop and evaluate improved interventions for people with OA. Our overarching aim is to provide patients with better outcomes and to support longer and more active lifestyles. The theme will address the needs of diverse population groups through advances in three types of interventions as below.
Aim: Improve durability of hip, knee and ankle joint replacement through enhanced pre-clinical testing,
Population stratification and development of international standards for industry testing by stratifying for population needs, addressing the inherent variability in patient anatomy and disease state and in surgical delivery. Working with industry partners we will reduce the variability and improve function, reliability and patient outcomes in hip, knee and ankle joint replacement.
Aim: To develop biological acellular scaffolds which can be matched as closely as possible to the properties of the natural tissue to be replaced and develop and apply robust pre-clinical stratified simulation test methods for biological scaffolds in natural joints.
Aim: To use our extensive imaging experience, facilities and unique statistical shape modelling image analysis capabilities to understand temporal and spatial relationships of osteoarthritis pathologies so we can define early osteoarthritis phenotypes for novel pathology-targeted therapies
As a direct result of the establishment of the LMBRU, a Joint Replacement Technologies Group was created, which centres on partnerships between orthopaedic surgeons, biomechanists, radiologists and engineers combining to work on the clinical challenges surrounding joint replacement technologies from a truly multidisciplinary perspective. In the spine, novel work is being undertaken to develop novel protocols for creation of 3D motion and MRI models to inform sophisticated computational models of the function of internal structures defined from surface mounted marker sets. A series of major studies investigating hip, knee and ankle function in patients following joint replacement surgery captures the essence of the bench to bedside and back again bi-directional translational pathway, feeding clinical data into refined models of implant function in silico in the design phase and in vitro in the testing phase. A number of industrial partnerships have been built with the providers of the enabling technology and are examples of the translational role of the LMBRU in developing technologies and techniques with clinical and commercial relevance. The Joint Replacement Technologies group meets monthly at Chapel Allerton Hospital and is open to clinicians and researchers from around the region with an interest in collaborative research.
Contact Antony Redmond for more information firstname.lastname@example.org