Dr John Biglands


Clinical Scientist (Imaging)

Phone Number

0113 39 24473


Leeds Biomedical Research Centre (BRC)
Chapel Allerton Hospital
Chapeltown Road


After obtaining a first class BSc. in physics and computer science from Keele University John went on to obtain a MSc. in machine perception and neurocomputing. In 2002 he registered for basic training as an NHS medical physicist at the Leeds Teaching hospitals NHS trust obtaining a MSc. in Medical Physics from Leeds University. In 2004 he was employed at Leeds as an imaging physicist working in both magnetic resonance imaging and nuclear medicine. He achieved Health and Care Professional Council (HCPC) registration as a clinical scientist in 2007. In 2008 he was awarded an NIHR doctoral fellowship (£258,000) and was awarded a PhD in quantitative analysis of first pass myocardial perfusion in 2012. He obtained NIHR flexibility and sustainability funding (£36,714) for a further year of research in cardiac MRI.  Since 2013 John’s research time is split evenly between the cardiac MRI group and the LMBRU. In 2014 he was awarded honorary lecture status at the University of Leeds and he is active in the supervision of postgraduate and undergraduate project students and as a lecturer in MRI physics on the medical imaging modules run by the Division of medical physics.

Research Interests

John is an imaging physicist with a focus on quantitative magnetic resonance imaging specifically with applications in musculoskeletal and cardiac imaging. Current research includes the use of the following techniques:

  • Quantitative fat imaging using Dixon techniques
  • Diffusion imaging
  • T1 and T2 mapping
  • Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).

Working with clinical colleagues John is involved in optimising and implementing these techniques for application in studies investigating:

  • The normal ranges and reproducibility of quantitative MRI parameters in healthy muscle.
  • The ability of quantitative MRI to detect and monitor muscle tears in athletes.
  • The ability of quantitative MRI to assess the effect of glucocorticoid therapy in inflammatory diseases.
  • The use of quantitative DCE-MRI to assess the depth and rate of remission from rheumatoid arthritis in the hand in response to early biologic therapy.
  • The use of quantitative DCE-MRI to investigate the link between rheumatoid arthritis and myocardial changes in the heart.
  • Responses to rotator cuff tear repair surgery using fat quantitation.

Significant Publications